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Interpretation of Common Used Tumor Markers Affectedy by Systemic and Inflammatory Diseases
Čásová, Miroslava ; Topolčan, Ondřej (advisor) ; Ludvíková, Marie (referee) ; Šafarčík, Kristian (referee)
Interpretation of Common Used Tumor Markers Affected by Systemic and Inflammatory Diseases Introduction: An examination of tumor markers is often made as a basis for the successful diagnosis and follow-up treatment of patients with malignant tumors. However, are tumor markers truly significant by themselves, or are they just a baseline quantitative expression of value that we use to diagnose a patient as better or worse based on it increasing or decreasing value? Objective: This paper attempts to answer the question of what factors can affect serum protein and mucin markers and thus lead to a misinterpretation of their results. Methods: Tumor markers were determined by isotopic and non-isotopic laboratory analysis methods, using operational protocols of the immunoanalytic laboratory. All methods were checked using internal quality control, and four times a year using an external quality control. Additionally, 16 236 samples were analysed using 3180 probands during the period 2008-2014. Results: We discovered that in premenopausal women, the markers AFP, CA 125 and HE 4 rise during ovulation peak periods while other markers changed minimally or not at all. However, in postmenopausal women, we proved the incidence of a false positivity marker. With women in the 1st and 2nd trimester of pregnancy, the...
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New diets for patients on dialysis
Kubíková, Kristýna ; Matějková, Miroslava (advisor) ; Zakiyanov, Oskar (referee)
The bachelor thesis focuses on new diets for dialysis patients. The aim is to create a new dietary regime system that meets the dietary requirements during dialysis treatment and also make the work of nutritional therapists easier. The old system was based on "common rational diet no. 3" and the food was selected individualy for every patient in order to avoid unsuitable meals in the dietary regime. This system was rather time consuming and the nutritional values did not meet the requirements of a dialysis diet. The anatomy and physiology emphasis is placed especially on chronic renal insufficiency. The privotal point of this chapter is the dialysis treatment and a description of dietotherapy in this stage of kidney failure. The practical part looks as the methodology of creating a new dietary regime. The result part compares the improvement in nutritional values with the original "rational diet no.3" and also looks at the methodology of creating new dietary regimes. The main research goal of the questionnare was to find out the patient's satisfaction with the new dialysis diet. Another goal was to discover the nutritional balance of individual dishes and the willingness to continue the diet after hospitalization. Finally, I would also like to mention that theoretically prepared dietary regime was put...
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Interpretation of Common Used Tumor Markers Affectedy by Systemic and Inflammatory Diseases
Čásová, Miroslava ; Topolčan, Ondřej (advisor) ; Ludvíková, Marie (referee) ; Šafarčík, Kristian (referee)
Interpretation of Common Used Tumor Markers Affected by Systemic and Inflammatory Diseases Introduction: An examination of tumor markers is often made as a basis for the successful diagnosis and follow-up treatment of patients with malignant tumors. However, are tumor markers truly significant by themselves, or are they just a baseline quantitative expression of value that we use to diagnose a patient as better or worse based on it increasing or decreasing value? Objective: This paper attempts to answer the question of what factors can affect serum protein and mucin markers and thus lead to a misinterpretation of their results. Methods: Tumor markers were determined by isotopic and non-isotopic laboratory analysis methods, using operational protocols of the immunoanalytic laboratory. All methods were checked using internal quality control, and four times a year using an external quality control. Additionally, 16 236 samples were analysed using 3180 probands during the period 2008-2014. Results: We discovered that in premenopausal women, the markers AFP, CA 125 and HE 4 rise during ovulation peak periods while other markers changed minimally or not at all. However, in postmenopausal women, we proved the incidence of a false positivity marker. With women in the 1st and 2nd trimester of pregnancy, the...
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